As with many other log-tenured leagues, the Midwest League went through several name changes.  From 1947-1948 it was known as the Illinois State League.  For the next seven seasons it operated as the Mississippi-Ohio Valley League, until adopting the name Midwest League in 1956. The league was replaced by a reorganized High-A Central in 2021 but was renamed back to the Midwest League ahead of the 2022 season.

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C.C. Hoffman, 1956-1962

Walter C. Wagner, 1963-1964

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James Doster, 1966-1973

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William K. Walters, 1974-1986

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George Spelius, 1987-2014

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Richard A. Nussbaum, 2015-2020

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